NIH- and Department of Defense–funded surgeon-scientist. Dr. Jowett secured more than $5 million in combined grant and philanthropic support for facial reanimation, nerve repair, and gene-therapy research while directing the Surgical Photonics & Engineering Laboratory at Harvard Medical School and Mass Eye and Ear.
Uses viral vectors encoding fluorescent proteins to map the microanatomy of end-to-side neural coaptation — the same nerve-repair principle used in facial reanimation and corneal neurotization.
Explores AAV vector–based gene therapy for tuberous sclerosis, extending the lab’s viral-vector platform from peripheral nerve to the central nervous system.
Time-lapse super-resolution imaging of AAV trafficking in murine corneal sensory axons and Schwann cells.
Applies computer-vision assessment of laryngoscopy to diagnose laryngeal movement disorders.
Quantified Schwann-cell transduction with a novel capsid-engineered AAV vector for peripheral-nerve gene therapy.
Characterized viral transgene delivery to murine facial-nerve motor axons and Schwann cells.
Characterized relationships between facial surface EMG and facial displacement as a control signal for a hemifacial neuroprosthesis.
Tested adeno-associated virus gene therapy for peripheral-nerve repair in a murine model.
Core laboratory support for new therapies targeting complex head-and-neck deformities, including facial paralysis and nerve injury, at Massachusetts Eye and Ear.
Established a rodent paradigm for hemi-facial reanimation using an implantable neuroprosthetic device.
Advanced outcome analysis and surgical planning for facial reanimation.
Characterized heat generation during ultrafast laser ablation of tissue.
Examined osseointegration of a titanium implant after ultrafast laser ablation in a live rodent model.
Compared osseous and soft-tissue healing after ultrafast laser ablation versus conventional surgical techniques.
Studied how accurately medical trainees assess their own surgical-skill learning.