Viral Vector Functionalized Core-Shell Scaffold

What Is This Study About?

This international patent application covers a core-shell nerve guidance scaffold functionalized with a viral gene-delivery vehicle, typically an AAV vector. The construct is designed to bridge a nerve gap while releasing vector in a controlled gradient to promote directed axonal regeneration.

Key Findings

• Claims a core-shell nerve guidance scaffold loaded with a viral vector, including AAV
• Supports a concentration gradient of vector within the scaffold to guide regeneration
• Inventors Jowett and Wegst; applicants Massachusetts Eye and Ear Infirmary and Northeastern University

What This Means for Patients

A conduit that both physically guides axons and delivers gene therapy at the repair site is a path toward better recovery after nerve gaps that today require autograft or leave incomplete regeneration.